|
KMID : 0653819900160010007
|
|
Microorganisms and Industry
1990 Volume.16 No. 1 p.7 ~ p.17
|
|
|
The ras oncogenes in aflatoxin B-induced rat liver carcinomas
|
|
Kim Young-Soo
Min Kyung-Rak
Gerald N.Wogan
|
|
|
Abstract
|
|
|
|
In summary, the nature of the amino acid changes that impart oncogenicity in either the focus formation or tumorigenicity assay can be inferred by analysis of PCR-amplified DNA from tumor-derived NIH3T3 transformants and confirmed by analysis of primary liver tumors. Putative activating mutations in the c-K-ras genetic locus have been shown to involve a single-base modification of either G-C base pair at codon 12 leading to aspartate or cystein substitutions for glycine. The oncogenicity of an N-ras oncogene containing the N-ras C gene region may be related to an amino acid substitution of valine for glycine at codon 13.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|